Stereological evaluation of the volume and volume fraction of newborns’ brain compartment and brain in magnetic resonance images

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dc.contributor.author Nisari, Mehtap
dc.contributor.author Ertekin, Tolga
dc.contributor.author Özçelik, Özlem
dc.contributor.author Çınar, Şerife
dc.contributor.author Doğanay, Selim
dc.contributor.author Acer, Niyazi
dc.date.accessioned 2021-07-08T10:51:02Z
dc.date.available 2021-07-08T10:51:02Z
dc.date.issued 2012-11-01
dc.identifier.uri http://hdl.handle.net/20.500.11787/3746
dc.description.abstract Brain development in early life is thought to be critical period in neurodevelopmental disorder. Knowledge relating to this period is currently quite limited. This study aimed to evaluate the volume relation of total brain (TB), cerebrum, cerebellum and bulbus?pons by the use of Archimedes’ principle and stereological (point-counting) method and after that to compare these approaches with each other in newborns. Methods This study was carried out on five newborn cadavers mean weighing 2.220 ± 1.056 g with no signs of neuropathology. The mean (±SD) age of the subjects was 39.7 (±1.5) weeks. The volume and volume fraction of the total brain, cerebrum, cerebellum and bulbus?pons were determined on magnetic resonance (MR) images using the point-counting approach of stereological methods and by the use of fluid displacement technique. Results The mean (±SD) TB, cerebrum, cerebellum and bulbus?pons volumes by fluid displacement were 271.48 ± 78.3, 256.6 ± 71.8, 12.16 ± 6.1 and 2.72 ± 1.6 cm3 , respectively. By the Cavalieri principle (point-counting) using sagittal MRIs, they were 262.01 ± 74.9, 248.11 ± 68.03, 11.68 ± 6.1 and 2.21 ± 1.13 cm3 , respectively. The mean (± SD) volumes by point-counting technique using axial MR images were 288.06 ± 88.5, 275.2 ± 83.1, 19.75 ± 5.3 and 2.11 ± 0.7 cm3 , respectively. There were no differences between the fluid displacement and point-counting (using axial and sagittal images) for all structures (p[0.05). Conclusion This study presents the basic data for studies relative to newborn’s brain volume fractions according to two methods. Stereological (point-counting) estimation may be accepted a beneficial and new tool for neurological evaluation in vivo research of the brain. Based on these techniques we introduce here, the clinician may evaluate the growth of the brain in a more efficient and precise manner tr_TR
dc.language.iso eng tr_TR
dc.publisher Springer-Verlag tr_TR
dc.relation.isversionof 10.1007/s00276-012-0971-6 tr_TR
dc.rights info:eu-repo/semantics/openAccess tr_TR
dc.subject Stereology tr_TR
dc.subject Newborn tr_TR
dc.subject Brain tr_TR
dc.subject Volume estimation tr_TR
dc.title Stereological evaluation of the volume and volume fraction of newborns’ brain compartment and brain in magnetic resonance images tr_TR
dc.type article tr_TR
dc.relation.journal Surgical and radiologic anatomy tr_TR
dc.contributor.department Nevşehir Hacı Bektaş Veli Üniversitesi/diş hekimliği fakültesi/temel bilimler bölümü/temel tıp bilimleri anabilim dalı tr_TR
dc.contributor.authorID 43415 tr_TR
dc.identifier.volume 34 tr_TR
dc.identifier.issue 9 tr_TR
dc.identifier.startpage 825 tr_TR
dc.identifier.endpage 832 tr_TR


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