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A Study on the toxic effect of different doses of diclofenac sodium on the development of the Kidney in the Postnatal period

Mustafa, Hesham; Işınsu, Alkan; Ömür Gülsüm, Deniz; Berrin Zuhal, Altunkaynak; Ebru, Annaç; Süleyman, Kaplan (The Scientific Electronic Library Online, 2019-09)

The toxic effects of different doses of diclofenac sodium (DS) on the kidney on the postnatal period (0-7 days) by morphometrical and immunohistochemical methods were investigated. For this purpose, 15 female adult wistar ...
Effects of 900-mhz radiation on the hippocampus and cerebellum of adult rats and attenuation of such effects by folic acid and boswellia sacra

Elfide Gizem, Kıvrak; Berrin Zuhal, Altunkaynak; Işınsu, Alkan; Kıymet Kübra, Yurt; Adem, Kocaman; Mehmet Emin, Önger (The official journal of the Saudi Society of Microscopes, 2017)

The radiation emitted from mobile phones has various deleterious effects on human health. This study was conducted to evaluate the effects of exposure to the 900-MHz radiation electromagnetic fields (EMF) emitted by mobile ...
Effects of electromagnetic fields exposure on the antioxidant defense system

Elfide Gizem, Kıvrak; Kıymet Kübra, Yurt; Arife Ahsen, Kaplan; Işınsu, Alkan; Gamze, Altun (The official journal of the Saudi Society of Microscopes, 2017)

Technological devices have become essential components of daily life. However, their deleterious effects on the body, particularly on the nervous system, are well known. Electromagnetic fields (EMF) have various chemical ...
Effects of leptin on histomorphometry of liver in high-fat diet fed obese rats

Elfide, Kıvrak; Işınsu, Alkan; Gamze, Tümentemur; Zuhal, Altunkaynak; Süleyman, Kaplan (Ondokuz Mayıs Üniversitesi, 2013)

Obesity, a condition that is characterized by the excessive accumulation and storage of body fat, is one of the most significant and common diseases of today’s world and it is measured by a method called body mass index ...
Garcinia kola aqueous suspension prevents cerebellar neurodegeneration in long-term diabetic rat – a type 1 diabetes mellitus model

Mohammed, Farahna; Etet Paul, Seke; Sayed Y, Osman; Kıymet Kübra, Yurt; Naheed, Amir; Lorella, Vecchio; Işınsu, Alkan; Yousef H, Aldebas; Azimullah, Sheikh; John C, Chijuka; Süleyman, Kaplan; Abdu, Adem (Elsevier, 2017)

Ethnopharmacological relevance The development of compounds able to improve metabolic syndrome and mitigate complications caused by inappropriate glycemic control in type 1 diabetes mellitus is challenging. The medicinal ...
Hippocampal Neural Cell Loss in High-fat-diet Induced Obese Rats– Exploring the Protein Networks, Ultrastructure, Biochemical and Bioinformatical Markers

Işınsu, Alkan; Altunkaynak, Zuhal; İnal Gültekin , Güldal; Bayçu, Cengiz (Elsevier, 2021-05-22)

Objective: Obesity, which has become one of the main health problems, results from irregular and unhealthy nutrition. In particular, an increase in the intake of high-fat foods leads to obesity and associated disorders. ...
Histomorphometric changes in the placenta and umbilical cord during complications of pregnancy

Davut, Güven; Zuhal, Altunkaynak; Gamze, Altun; Işınsu, Alkan; İdris, Koçak (Taylor and Francis Online, 2018)

Pregnancy complications may cause morphological changes and circulation defects in the placenta, which may lead to morbidity and mortality in fetuses and newborns. We investigated structural changes in the placenta and ...
Is parturition-timing machinery related to the number of inhibitor cd94/nkg2a positive uterine natural killer cells?

Eser, Mazi; Zuhal, Altunkaynak; Işınsu, Alkan; İdris, Koçak; Davut, Güven; Aysın Pınar, Türkmen; Alişan, Yıldıran (Springer, 2016)

Purpose: Prematurity is the most common cause of infant mortality and morbidity. To prevent this, the timing of parturition and its mechanisms should be understood. It is likely that inhibitor CD94/NKG2A positive decidual ...
Is vagal stimulation or inhibition benefit on the regulation of the Stomach Brain Axis in Obesity?

Işınsu, Alkan; Zuhal, Altunkaynak; Elfide Gizem, Kıvrak; Arife Ahsen, Kaplan; Gülay, Arslan (Taylor and Francis Online, 2020-10-09)

Objective: Possible effects of the vagus inhibition and stimulation on the hypothalamic nuclei, myenteric plexes and the vagus nerve were investigated. Methods: The female rats divided to the inhibition (INH), stimulation ...
Periferik sinir için stereolojik inceleme yöntemi

Mehmet Emin, Önger; Gamze, Altun; Işınsu, Alkan; Elfide Gizem, Kıvrak; Kıymet Kübra, Yurt; Zuhal, Altunkaynak; Süleyman, Kaplan (Türkiye Klinikleri, 2014)

Periferik sinir hasarları ve hastalıklarının klinik önemine işaret eden kantitatif araştırmalar gün geçtikçe artmaktadır. Sinir hasar ve rejenerasyonunda toplam miyelinli akson sayısı en önemli nöropatolojik parametrelerden ...
The investigation of the effects of Topiramate on the Hypothalamic levels of Fat mass/obesity-associated Protein and Neuropeptide Y in Obese Female Rats

Işınsu, Alkan; Zuhal, Altunkaynak; Gamze, Altun; Erkan, Erener (Taylor and Francis, 2019)

Objective: The aim of the present study is to investigate the effects of topiramate on the fat mass/obesity-associated protein (FTO) and on the neuropeptide Y (NPY) level in the hypothalamus depending on the recently ...
The Morphometrical and Immunohistochemical Investigation of the Effect of Topiramate on Liver and the Role of NeuropeptideY Receptor in an Obese Female Rat

Ahmad, Yahyazadeh; Berrin Zuhal, Altunkaynak; Işınsu, Alkan (AEPress, 2020-08-20)

OBJECTIVE: We aimed to investigate the possible effect of topiramate (TOP, 0.02 mg/kg/day) on the livers in a high-fat diet (HFD)-induced obesity rat model. The other objective was to evaluate the relationship between TOP ...
The protective effect of curcumin on the diabetic Rat Kidney: A stereological, electron microscopic and immunohistochemical study

Mahmut, Ulubay; Işınsu, Alkan; Kıymet Kübra, Yurt; Süleyman, Kaplan (Elsevier, 2020-02)

The prevalence of diabetes in the world is increasing rapidly. Kidney diseases are among the most common medical disorders. The aim of this study was to investigate the effect of curcumin on the diabetic kidney. Thirty-five ...