Abstract:
Hydroxyapatite undoubtedly has vital roles in tissue engineering applications. The fabrication
methods and different treatments lead distinct properties in hydroxyapatite crystals, including
particle, size, shape, and surface features. In this study, we applied sol-gel synthesis route for
hydroxyapatite production which offers relatively cost available and high yield of product.
The influence of initial pH parameter and various temperature treatments on properties of
hydroxyapatite were investigated. The leading hydroxyapatite powders have been compared
in terms of their morphological and chemical structures by XRD and SEM analyses. The
incipient pH in which the precursor solutions introduced to one another had critical role in
this synthesis reaction. This has determined major properties, such as the chemical
composition, phase purity, product yield, and morphology. The reactions of precursor
solutions with higher incipient pH contributed to high yield (86%) of pure HA possessing
high thermal stability. On the other hand, in lower incipient pH (8) counterpart, β-TCP phase
was detected upon treatment at 950 °C. We had used the acquired pure HA in dried form in
chitosan based injectable hydrogel compositions with pro-angiogenic features designed for
bone tissue regeneration and drug delivery applications.
