Synthesis of new calix[4]arene amide derivatives and investigation of their DNA cleavage activity

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dc.contributor.author Özkan, Şeyda Çiğdem
dc.contributor.author Yılmaz, Aydan
dc.contributor.author Özmen, İsmail
dc.date.accessioned 2021-05-24T09:03:33Z
dc.date.available 2021-05-24T09:03:33Z
dc.date.issued 2013
dc.identifier.uri http://hdl.handle.net/20.500.11787/1590
dc.description.abstract This study comprises the synthesis of new p-tert-butylcalix[4]arene with different amide functional groups and summarises an investigation of their DNA cleavage activities. The structural investigations of the synthesised compounds were examined by FTIR, 1H NMR, 13C NMR, elemental analysis and FAB-MS techniques. The interaction between these compounds and pBR322 plasmid DNA has been investigated via agarose gel electrophoresis and, according to the results, compounds 5, 7, 8 and 13 exhibit efficient DNA cleavage activity. In the electrophoresis images of 5, 7 and 8, Form IV which is small DNA fragment was observed in addition to supercoiled Form I, open circular Form II and linear Form III. tr_TR
dc.language.iso eng tr_TR
dc.relation.isversionof 10.1080/10610278.2013.817578 tr_TR
dc.rights info:eu-repo/semantics/openAccess tr_TR
dc.subject Acıgöl tr_TR
dc.subject Kimya tr_TR
dc.title Synthesis of new calix[4]arene amide derivatives and investigation of their DNA cleavage activity tr_TR
dc.type article tr_TR
dc.relation.journal Supramolecular Chemistry tr_TR
dc.contributor.authorID 228856 tr_TR
dc.identifier.volume 26 tr_TR
dc.identifier.issue 1 tr_TR
dc.identifier.startpage 25 tr_TR
dc.identifier.endpage 31 tr_TR


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