Abstract:
Objective: In this study, normal values of the newborn brain’s
volume and surface area were calculated for the early diagnosis of disease related to the central nervous system which may
develop in newborns.
Materials and Methods: In this study we investigated MRI images of 5 newborn cadavers. Stereologic measurements were
performed to calculate the volume and surface area of the
brain. We used Archimedes principle as a gold standard and
the point counting method as a stereologic method for volume
estimation of the newborn brains. Cycloid probe was superimposed on images,which were obtained by using the vertical
section method, for suface area estimation of the brain and
then results were obtained.
Results: We estimated the mean cerebral volume as 246±79.4
cm3
and 256±71.1cm3
, by the point counting technique and
gold standard, respectively. We estimated cerebral surface area
using the vertical section method in 4 orientations, the results
were 210±41, 202±36.4 cm2
, 267±41 cm2
and 293±52.6 cm2
two post processing, coronal and sagittal planes, respectively.
Conclusion: We consider that our study will be a good source
for similar studies performed in future.