A new stationary phase for hydrophilic interaction chromatography: Polyacrylate‑based hydrophilic, monosized‑porous beads with zwitterionic molecular brushes

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dc.contributor.author Çelebi, Bekir
dc.contributor.author Özen, Mürüvvet Begüm
dc.contributor.author Kip, Çiğdem
dc.contributor.author Tuncel, Ali
dc.date.accessioned 2022-12-05T06:45:46Z
dc.date.available 2022-12-05T06:45:46Z
dc.date.issued 2014-09-03
dc.identifier.uri http://hdl.handle.net/20.500.11787/7782
dc.description.abstract Hydrophilic, polyacrylate-based, monosizedporous beads with zwitterionic molecular brushes were synthesized as a new stationary medium for hydrophilic interaction chromatography. Monosized-porous poly(glycerol1,3-diglycerolate diacrylate-co-glycerol dimethacrylate), poly(GDGDA-co-GDMA), beads 5 μm in size were obtained by a staged-shape template polymerization. As an initiator for surface-initiated atom transfer radical polymerization (SIATRP), bromine functionality was obtained on the beads by reacting their hydroxyl groups with 3-(aminopropyl)triethoxy silane and α-bromoisobutyryl bromide, respectively. Zwitterionic molecular brushes on the hydrophilic poly(GDGDA-coGDMA) beads were generated by SI-ATRP of a sulfobetaine monomer, [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium hydroxide (MESH). Poly(MESH)-grafted poly(GDGDA-co-GDMA), poly(MESH)g-poly(GDGDAcoGDMA), beads were slurry packed into the microbore columns with 2 mm i.d. and evaluated as stationary medium for the separation of organic acids, nucleosides and peptides using microbore columns in hydrophilic interaction chromatography with the plate numbers up to 30,000 plates 1/m. tr_TR
dc.language.iso eng tr_TR
dc.rights info:eu-repo/semantics/openAccess tr_TR
dc.subject Hydrophilic interaction chromatography tr_TR
dc.subject HPLC tr_TR
dc.subject Monodisperse porous particles tr_TR
dc.subject Chromatographic packing tr_TR
dc.subject Peptides tr_TR
dc.subject Ethylene dimethacrylate tr_TR
dc.title A new stationary phase for hydrophilic interaction chromatography: Polyacrylate‑based hydrophilic, monosized‑porous beads with zwitterionic molecular brushes tr_TR
dc.type article tr_TR
dc.relation.journal Chromatographia tr_TR
dc.contributor.department Nevşehir Hacı Bektaş Veli Üniversitesi/fen-edebiyat fakültesi/kimya bölümü/fizikokimya anabilim dalı tr_TR
dc.contributor.authorID 332715 tr_TR
dc.identifier.volume 77 tr_TR
dc.identifier.startpage 1511 tr_TR
dc.identifier.endpage 1520 tr_TR


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